激光激活微型胶囊可以将药物输送到身体特定部位

来源:cnBeta.COM    关键词:激光激活, 胶囊, 药物,    发布时间:2019-07-26

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治疗癌症等严重疾病涉的并发症之一是药物必须在整个身体内循环,造成更多副作用。长期以来,医务人员一直在寻找将化疗等严厉治疗方法直接传递给身体特定区域受影响细胞的方法。加州理工学院工程与应用科学系研究人员认为,他们有一种新颖方法可以在体内有针对性地提供药物。


研究人员开发了可以将药物输送到身体特定区域的微型药物。这些微型药物不仅可以将药物输送到身体的特定部位,而且它们可以从身体外部进行控制和监测。微型微粒是由金属镁制成的微小球体,表面覆盖着一层薄薄的金和聚乙烯。后者是一种抗消化的聚合物。


覆盖层使球体的圆形部分不被覆盖,从而使镁与消化道中的液体反应并产生小气泡。产生的气泡流就像一股射流,推动球体向前移动,直到撞击到组织上。药物层夹在单个微球和聚对二甲苯涂层之间。为了在胃部起到额外的保护作用,球体也被涂上石蜡制成的微囊。球体能够以这种形态输送药物,但无法到达身体内所需的位置。



为了引导微型药物找到正确的身体部位,研究小组使用了光声计算机断层扫描(PACT)。这项技术使用红外激光脉冲,当微型药物在肿瘤附近时,红外激光束会短暂地加热微型药物,熔化蜡囊,使其暴露在胃酸中,然后展开药物治疗。科学家们说,一些微型药物会贴在需要药品的地方,而有些则不会。


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